This study was designed to investigate the hepatoprotective potential
of calcium and magnesium against lead and cadmium induced hepatotoxicity
using a rat model. Varying concentrations of cadmium and lead salts in
combination were used to induce liver damage. This was followed by adding
varying concentrations of calcium and magnesium salts in combination to
the same concentration used to induce liver damage. The degree of damage
and protection were measured using biochemical parameters such as serum-glutamate-pyruvate
transaminases (SGPT), serum-glutamate-oxaloacetate transaminases (SGOT),
total protein, albumin and histopathological examination of the liver
cells. Studies indicate that liver function is generally impeded particularly
with respect to albumin synthesis and the cellular integrity of the organ
is damaged as a function of elevations in cadmium and lead concentrations.
The albumin concentration decreased as the concentrations of cadmium and
lead were increased from control thus: 4.25±0.40 g/100 mL; 3.63±0.17
g/100 mL; 3.50±0.13 g/100 mL; 3.38±0.19 g/100 mL and 3.38±0.29
g/100 mL, respectively, while SGPT and SGOT were increasing. The addition
of calcium and magnesium to the same combined concentrations of cadmium
and lead which caused albumin synthesis impairment in the first phase
of this research protected the liver as the albumin concentrations were
not significantly different from control. The albumin concentrations were:
3.70±0.18 g/100 mL; 3.88±0.38 g/100 mL; 3.75±0.18
g/100 mL; 3.60±0.44 g/100 mL and 3.88±0.36 g/100 mL, respectively.
Histopathological studies on the liver confirmed the protective potential
of calcium and magnesium on the hepatotoxicity arising from cadmium and
lead as the damage observed in phase 1 of this research using the same
concentrations is obliterated.
J.D. Dabak, S.Y. Gazuwa and G.A. Ubom, 2009. Hepatoprotective Potential of Calcium and Magnesium Against Cadmium and Lead Induced Hepatotoxicity in Wistar Rats. Asian Journal of Biotechnology, 1: 12-19.