Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
American Journal of Biochemistry and Molecular Biology
  Year: 2011 | Volume: 1 | Issue: 3 | Page No.: 244-254
DOI: 10.3923/ajbmb.2011.244.254
Coagulation Factors Evaluation in NIDDM Patients
Maysam Mard-Soltani, Mohammad Reza Dayer, Ghasem Ataie, Ahmad Ali Moazedi, Mohammad Saaid Dayer and Sayed Mohammad Reza Alavi

Abstract:
Diabetes mellitus is the major risk factor for vascular diseases presumably by inducing hypercoagulable state leading to thrombotic plaque in small blood vessels. There are miscellaneous reports showing the intervention of some coagulation factors/co-factors, especially I, II, V, VII, VIII, IX, X, XI, vonWillebrand and tissue factor in micro and macrovascular complications. In the present we used 40 uniformed NIDDM patients and 21 healthy volunteers as control for the study. Based on the results obtained for coagulation tests such as PT, APTT and the specific activity or concentration determination for factors I, II, V, VII, VIII, IX, X, X and von Willebrand, we made a new comprehensive comparison between NIDDM and healthy groups. Present results show the major interference of intrinsic and common pathway of coagulation cascade factors and less of extrinsic pathway in hypercoagulability state in NIDDM patients. Present results show that there are significant increase (p<0.05) in plasma activities of coagulation factors, FII, FIX, FXI in intrinsic and common pathways and significant decrease in activity of factor VIII and prolonged prothrombin time in NIDDM patients (n = 40) in contrast to normal controls (n = 21). This finding leads us to conclude that this pattern could be used as diagnostic criteria for the presence of hypercoagulable state and as prognostic tools for susceptibility to vascular disease in NIDDM patients. Second, our findings in conjunction with patients history indicates that the presence of hypercoagulable state is not sufficient to induced vascular problems in NIDDM and instead it need additional triggering factors to initiate vascular thrombotic problems e.g., endothelium damage.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    The Buffering Role of HDL in Balancing the Effects of Hypercoagulable State in Type 2 Diabetes
  •    Synthesis of Some Pyrrole Derivatives and their Anticoagulant Activity
  •    Biochemical Indices of Macrovascular Complication in Diabetic Rat Model: Compared Effects of Vernonia amygdalina, Catharantus roseus and Chlorpropamide
  •    Diabetic Complications: Influence of Age, Sex, Family History, Duration, Glycemic Control and Obesity
  •    Microvascular Complications of Diabetes
  •    Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis
How to cite this article:

Maysam Mard-Soltani, Mohammad Reza Dayer, Ghasem Ataie, Ahmad Ali Moazedi, Mohammad Saaid Dayer and Sayed Mohammad Reza Alavi, 2011. Coagulation Factors Evaluation in NIDDM Patients. American Journal of Biochemistry and Molecular Biology, 1: 244-254.

DOI: 10.3923/ajbmb.2011.244.254

URL: http://scialert.net/abstract/?doi=ajbmb.2011.244.254

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved