Aim of the present study was to determine whether chronic urticaria or alopecia areata are statistically associated with thyroid dysfunction and/or thyroid autoimmunity in Egyptian population. The study comprised 35 CIU patients (mean age 28.1±10.2 years, 22 female versus 13 male) and 20 AA patients (mean age 27.2±12 years, 13 female and 7 male) as well as 30 control subjects (19 female and eleven male, mean age 26.3±12.2 years). All patients and control were subjected to thorough history taking, complete physical examination and routine laboratory tests. CIU and AA patients were otherwise clinically free and receive no medications. Free T3 (FT3), free T4 (FT4), Thyroid Stimulating Hormone (TSH), antithyroid peroxidase (TPA) and anti thyroglobulin (TGA) autoantibodies were evaluated for all patients and controls. On laboratory basis, clinical and subclinical thyroid disease was detected in 42.8% of CIU patients and 33.3% of AA patients versus subclinical hyperthyroidism detected in two control subjects. Mean serum levels of TSH, TPA and TGA were significantly higher in CIU patients or AA patients than control. This finding was preserved when comparing female CIU or AA patients with female control and male CIU and AA patients with male control. TPA was positive 14.2% of our CIU patients, TGA was found to be high in 20% of CIU patients. Moreover TGA was found to be high in 15% of AA patients, TPA tested +ve in 10% of our AA patients and equivocal in 15% of AA patients. No significant correlation between TPA or TGA and thyroid hormones in either CIU or AA patients was detected. Screenings for thyroid function and thyroid ultrasound are advisable in patients with CIU as well as AA patients for early detection of thyroid dysfunction. CIU and AA could help to discover a possible silent pathology of the thyroid gland in clinically euthyroid patients.
M.A. El Gayyar, M.I. Helmy, Afaf Abdelhafez, N.A. Omran and E.R. Amer, 2011. Evaluation of Thyroid Hormone Abnormalities and Thyroid Autoantibodies in Chronic Idiopathic Urticaria and Alopecia Areata Egyptian Patients. Asian Journal of Dermatology, 3: 1-12.