Abstract:
Methoxy poly (ethylene glycol)-b-poly (D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) films containing a poorly water-soluble drug were prepared by evaporation method of MPEG-b-PDLLG and drug solution in dichloromethane. Ibuprofen was used as a poorly water-insoluble model drug. Influences of MPEG block length and DLL/G ratio on drug-loaded film character and drug release behavior were investigated. Inhibition of entrapped ibuprofen crystallization in the MPEG-b-PDLLG films was observed from thermal analysis. The drug release rates increased as the MPEG block length increased. Incorporation of G units in the PDLL block also induced the faster drug release rate. The drug had released from the films through diffusion mechanism.
Y. Baimark and T. Phromsopha, 2009. Methoxy Poly Ethylene Glycol-b-poly (D, L-lactide-co-glycolide) Films as Drug Delivery Systems for Ibuprofen. Asian Journal of Scientific Research, 2: 87-95.
07 June, 2009
murthy murali: methoxy poly (ethylene glycol)-b-poly (D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) films containing a poorly water-soluble drug were prepared by evaporation method of MPEG-b-PDLLG and drug solution in dichloromethane.
is this require to release for films
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