Genetically modified (GM) crops are cultivated presently in more than 40 million hectares in more than 13 countries in the World. The GM technology contained introduced microbial genes that provide tolerance to broad-spectrum herbicides such as glufosinate or glyophosate and resistance to pest and diseases. The continuous search for disease control strategies in crop production and the prospect of meeting the goals of global sustainable food crop production, has led to a significant interest in the GM technology as a modern tool for the introduction of disease resistance in crops. This review document attempts to discuss the progress of GM technology as a vital tool for the engineering of pathogen resistance in crops, the evolution of cloned disease resistance genes and the level of success of the GM disease resistant crops in commercial release. The GM technologies have the potential for producing improved high yielding disease resistant crops and better quality food products for consumption.