The present study aimed to ascertain the current situation of antimicrobial resistance of Urinary Tract Infections (UTIs) caused by human pathogens. Ten midstream urine samples were collected from adult patients were analyzed for Multidrug Resistant (MDR) strain isolation and identified. The result was clear that E. coli was the predominant pathogen (31.5%) causing UTI, followed by Staphylococcus aureus(20.5%), Klebsiella pneumonia (15.8%), Proteus sp. (7.4%) andPseudomonas aeruginosa(7.5%). The percentages of resistance of all isolates to the antimicrobial agents were: 83.3% to SXT, 80.6% to Nalidixic acid, 67.3% to Amoxycillin, 61% to Cotrimoxazole, 48.8% to Gentamycin, 46% to ciprofloxacin and 43% to Cephalexin. Isolated UTI strains were tested for susceptibility against antibiotics, few of the antibiotics were sensitive but most of antibiotics showed resistant to the MDR strains. Among this E. coli, K. pneumoniae and P. aeruginosa were highly resistance to most of the antibiotics, whereas Staphylococcus sp. and Serratia marcescens exhibited sensitive to Cephalexin, Ciprofloxacin and Gentamycin. The present study was evaluated for the prevalence of micrograms implicated in UTI to ascertain their antimicrobial resistance patterns and indicates emerging multidrug resistance among UTI bacterial pathogens.