The present study was designed to determine the effects
of atorvastatin on C-Reactive Protein (CRP) and lipid profile in patients
with stroke, since their anti-inflammatory properties have been investigated
recently. Ninety five patients with or without stroke were recruited for
the study, of which 60 belongs to control (untreated) and 35 were test
group (treated) and received daily with 10 mg day-1 of atorvastatin.
The patients were followed for over a period of 3 months. For entire study
population, CRP along with lipid profile, Serum Glutamic Oxaloacetic Transaminase
(SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) were measured 1st
day and at the end of 3rd month of the treatment. Treatment with atorvastatin
decreases both inflammatory activity and atherogenic lipoproteins. The
results of this study will provide important information on how to maximize
the therapeutic benefits of atorvastatin in a broader range of patients
at risk for cerebrovascular morbidity and mortality.
A. Vijaya Anand, M. Chandrasekharan, S. Kalavathy, K. Uma, M.P. Saravanan, A. Mohamed Saleem Gani, K. Vijaya Kumar, R. Senthil and P. Sampath Kumar, 2009. The Influencing Aspects of Atorvastatin on C-Reactive Protein and Lipid Profile in Patients with Stroke. International Journal of Biological Chemistry, 3: 30-34.