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International Journal of Cancer Research
  Year: 2009 | Volume: 5 | Issue: 3 | Page No.: 105-114
DOI: 10.3923/ijcr.2009.105.114
Cytotoxic and Anti-Angiogenic Properties of the Stem Bark Extract of Sandoricum koetjape
A.F.A. Aisha, H.B. Sahib, K.M. Abu-Salah, Y. Darwis and A.M.S. Abdul Majid

Abstract:
Cytotoxic and anti-angiogenic properties of n-hexane extract of Sandoricum koetjape stem bark were investigated in vitro. 2,3-bis-(2-methoxy-4-nitro- 5-sulfophenyl)-2H-tetrazolium- 5-carboxanilide (XTT) cell proliferation assay was used to study the cytotoxic properties on Human Umbilical Vein Endothelial Cell (HUVEC) and both colon cancer and normal cell lines; HCT-116, HT-29 and CCD-18CO. Rat aorta ring assay was used to study the anti-angiogenic properties of the extract. At 100 μg mL-1, the extract showed 94±5.5% inhibition of the outgrowth of the blood vessels from the rat aorta rings. The extract also showed a dose dependent growth inhibition of all tested cell lines, IC50 values against HCT-116, HUVEC, CCD-18CO and HT-29 were 14, 23, 50 and 52 μg mL-1, respectively. At 50 μg mL-1, the extract had potently induced apoptotic cell death of HCT-116 colon cancer cell line by inducing caspases 3 and 7 activity. These results showed that n-hexane extract of S. koetjape possess both anti-angiogenic and apoptotic properties on colon cancer cell lines making it a good candidate for further studies.
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How to cite this article:

A.F.A. Aisha, H.B. Sahib, K.M. Abu-Salah, Y. Darwis and A.M.S. Abdul Majid, 2009. Cytotoxic and Anti-Angiogenic Properties of the Stem Bark Extract of Sandoricum koetjape. International Journal of Cancer Research, 5: 105-114.

DOI: 10.3923/ijcr.2009.105.114

URL: http://scialert.net/abstract/?doi=ijcr.2009.105.114

COMMENTS
21 September, 2015
Martin Chandra Putra Manurung:
Good Morning... My nationality is a citizen of Indonesia... Could you mind giving or suggesting to me another journal about bark sandoricum koetjape..? I'm still making a thesis for my scholar... Thank you
 
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