Chemical contaminants in milk comprise chemical hazards that may introduce during milk production, dairy processing or packaging. Veterinary drugs, heavy metals, radionuclides, mycotoxins and pesticides are chemical contaminants that can enter to animal feed and they have some residues in milk. The most contentious residues that occur in milk are antimicrobial drugs. They have some hazards for humans who consume milk and dairy products. Government and producer must apply some methods and plans for prevention and control of chemical contaminants in milk and dairy products. Total quality management and the Hazard Analysis Critical Control Points (HACCP) approach has an important role for preventing and controlling of chemical contaminants in milk and dairy products, especially antibiotics in raw milk shipped from the farm. This study would have a review of materials and sources of chemical contaminants, public health concerns and the methods of for controlling of these contaminants in milk and dairy products.