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International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 335-340
Research Article

Resveratrol, a Phytoalexin Enhances Hepatic Antioxidant Defense in 1,2-dimethylhydrazine-induced Colon Carcinogenesis

Murugan Sengottuvelan
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India
Namasivayam Nalini
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India
The effect of resveratrol supplementation on the carcinogenic response, hepatic lipid peroxidation and antioxidant levels/activities of rats administered with 1,2-dimethylhydrazine (DMH) (20 mg kg-1 body weight) was studied in male albino Wistar rats. DMH-induced oxidative stress (increased lipid peroxidation and decreased antioxidant defense) was modulated by oral administration of resveratrol (8 mg kg-1 body weight). Liver lipid peroxidation markers CD, LOOHs and TBARS were increased, in contrast hepatic antioxidants enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferases, glutathione reductase, reduced glutathione, Vitamin C and E activities/levels were decreased on DMH administration. Resveratrol supplementation in three dietary regimens (initiation, post-initiation and entire period) attenuated the liver lipid peroxidation with concomitant up-regulation of enzymic and nonenzymic antioxidant reserves. The reversal of oxidative stress was more pronounced in the entire period resveratrol supplementation. In conclusion resveratrol, a natural product is a suitable candidate as a chemopreventive agent in suppressing the adverse effect of DMH-induced oxidative stress.
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