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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 252-257
DOI: 10.3923/ijp.2008.252.257
Gastroprotective and Antioxidant Activities of the Roots of Hibiscus aculeatus Roxb in Rats
J. Anbu Jeba Sunilson, R. Varatharajan, P. Jayaraj, T. John, J. Jisha and P. Promwichit

Abstract:
Ethanol extract of Hibiscus aculeatus (HAE) was assessed in different acute and chronic gastric ulcer models in rats. HAE, 50-200 mg kg-1 administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (9.21-52.63% protection, p<0.05), aspirin (23.95-56.25% protection, p<0.05), ethanol (13.55-58.47% protection, p<0.05), cold-restraint stress (18.34-72.92% protection, p<0.05 to p<0.001) and acetic acid (p<0.05 to p<0.001) induced acute and chronic ulcers. HAE also significantly (p<0.001) reduced the ulcer incidence (40 and 10%) and severity (54.35 and 85.37% protection) of duodenal ulcer, induced by cysteamine. HAE offered protection (49.57 and 58.97%) against ethanol-induced depletion of gastric wall mucus. And also, HAE reduced the ulcer index with significant decrease in plasma corticosterone (21.15 and 33.51% protection, p<0.05), lipid peroxidation (16.66 and 38.88% protection, p<0.01 and p<0.001), superoxide dismutase (17.64 and 47.25% protection, p<0.05 and p<0.001) and an increase in catalase (25.84 and 83.14% protection, p<0.05 and p<0.001) activity respectively. Preliminary phytochemical screening of the HAE showed positive test for flavanoids, terpenoids, steroids, tannins and saponins. The results indicate that HAE possesses gastroprotective and antioxidant activity.
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How to cite this article:

J. Anbu Jeba Sunilson, R. Varatharajan, P. Jayaraj, T. John, J. Jisha and P. Promwichit, 2008. Gastroprotective and Antioxidant Activities of the Roots of Hibiscus aculeatus Roxb in Rats. International Journal of Pharmacology, 4: 252-257.

DOI: 10.3923/ijp.2008.252.257

URL: http://scialert.net/abstract/?doi=ijp.2008.252.257

COMMENTS
17 July, 2009
Chukwugozie Okwsuosa:
I need to read the entire document in order to make comments
20 July, 2009
Dr. Sunilson:

Already the entire article is freely accessible to all.

 
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