Abstract:
The aim of this study is the evaluation of the effect
of one group of surfactants including polyethylene glycol sorbitan esters
(Tweens: 20, 40, 60 and 80) on Red Blood Cells (RBC) as a model for biological
membranes. Also in this study some of physicochemical properties including
Emulsification index (E24) and Foam producing activity (Fh)
were studied. In this study the hemolytic effect of four surfactants from
Tween category were evaluated. Surfactants solutions were prepared in
McIvan`s buffer in specific concentration. 0.2 mL of RBC was mixed with
0.2 mL of one of surfactants solution incubated in four different temperatures
for two different times. The absorbance of the samples was determined
by UV spectrophotometer. Each test was done nine times. The results were
shown by mean±SD. E24 and Fh were also determined
for each surfactant solutions. In comparison of the four studied surfactants,
Tween 20 have the highest hemolytic effect and the Tween 80 is the lowest
one. The values of E24 and Fh have good correlation
with Hydrophilic-Lipophilic Balance (HLB) values. Increasing in HLB value
lead to increasing in those parameters.
Gholamreza Dehghan Noudeh, Payam Khazaeli and Pedram Rahmani, 2008. Study of the Effects of Polyethylene Glycol Sorbitan Esters Surfactants Group on Biological Membranes. International Journal of Pharmacology, 4: 27-33.
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