Abstract:
In the present study, Livobond was evaluated for its
hepatoprotective effects against carbon tetrachloride-induced hepatocellular
injury in rats. Hepatotoxicity was induced in male Sprague-Dawley rats
by intraperitoneal injection of CCl4 (1.5 mL kg-1)
in olive oil (1:1). Livobond at a dose of 500 and 750 mg/kg/day and silymarin
standard 50 mg/kg/day was administered orally for 7 days. The hepatoprotective
effect of Livobond and standard was evaluated by the assay of biochemical
parameters viz., alanine aminotransaminase (ALT), aspartate aminotransaminase
(AST), alkaline phosphatase (ALP), total and direct bilirubin, liver lipid
peroxidation, total proteins, catalase and by histopathological studies
of the liver. The toxic effects of CCl4 in Livobond treated
group was controlled significantly by restoration of the levels of serum
bilirubin, proteins and enzymes as compared to the CCl4 treated
and silymarin treated groups. Histopathological studies further confirmed
the hepatoprotective activity of Livobond. The results suggest that Livobond
is able to significantly alleviate the hepatotoxicity induced by CCL4
and may be attributed to the antioxidant property of the formulation.
Usha S. Satyapal, Vilasrao J. Kadam and Rumi Ghosh, 2008. Hepatoprotective Activity of Livobond A Polyherbal Formulation Against CCl4 Induced Hepatotoxicity in Rats. International Journal of Pharmacology, 4: 472-476.
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