The aim of this study is to screen the hexane, dicholoromethane,
ethyl acetate and methanol extracts of Pereskia bleo (PB) for their
antibacterial, anti-oxidant and anti-cancer properties using disc diffusion
method, DPPH assay and MTT cytotoxicity test, respectively. It is found
that hexane and methanol extracts showed highly and moderately, respectively,
considerable antibacterial activity towards two Gram-negative bacteria,
P. aeruginosa 60690 and S. choleraesuis. Ethyl acetate extract
showed a week narrow spectrum activity ( ≈ 35% of streptomycin activity).
The highest antibacterial activity on MRSA is obtained by DCM extract.
Hexane extract was the most effective DPPH radical scavenger (37.55%).
Ethyl acetate and DCM extracts were less effective free radical scavenger
(16.1%). None of the extracts were cytotoxic significantly towards MCF-7,
HT-29 and CEM-SS cell lines after 72 h incubation time (IC50
> 30 μg mL-1). It could be concluded that antibacterial
activity of P. bleo is the most promising biological activity attributed
to this plant.