Abstract:
In the present investigation, antidiabetic and antioxidant activities of a polyherbomineral formulation, Gly-13-C was evaluated in streptozotocin-induced diabetic male Wistar rats and compared with that of glibenclamide (600 μg kg-1), a reference drug. After induction of diabetes by a single intraperitoneal injection of streptozotocin (65 mg kg-1), diabetic animals were treated with different doses of Gly-13-C (100, 200 mg kg-1 and 400 mg kg-1 b.wt.) for 21 days. Various biochemical parameters-fasting plasma glucose, albumin fructosamine levels, liver enzymatic antioxidants like superoxide dismutase, catalase, non-enzymatic antioxidants like vitamin C and E, lipid peroxidation in liver and glycogen biosynthesis in liver and skeletal muscle were measured. Study results showed that Gly-13-C 200 and 400 mg kg-1 b.wt. demonstrated better glycemic control and significantly protected liver tissue against oxidative damage than reference drug.
P. Ashok, A. Kyada, P. Subbarao, S. Suthar, D. Singh and K. Vadaliya, 2010. Antioxidant Status of a Polyherbomineral Formulation (Gly-13-C) in STZ-Diabetic Rats. International Journal of Pharmacology, 6: 157-172.
04 August, 2010
Shaikh Azhar Hussain: paper was good but you didnt gave the preperation of polyherbal formulation, please send me the soft copy of your thesis on azharhussain24@yahoo.com. thanking you
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