Many plant-based medicines being used in treatment of HIV infections, but no scientific evidence are available to support their use. A number of synthetic, semi synthetic as well as drug of natural origin are reported to be active against HIV. In the present study, various drugs of plants and synthetic drugs have been discussed for some future beneficial combinations for formulations against viral infections. The combination therapy of the mentioned herbal agents with synthetic drugs might be beneficial for the treatment of retroviral infections in future due to better compatibility, potency and synergistic activities. New era of therapy can be developed by combination of synthetic, semi synthetic and natural drugs in pharmaceutical formulations.