The objective of this study is to carry out a suitable length of inflow record using in the simulation model. The second objective is to find an effect of initial reservoir capacity of reservoir simulation for searching the optimal rule curves. The reservoir simulation model was connected with genetic algorithms to search the optimal rule curves quickly. The model has been applied to determine the optimal rule curves of the Bhumibol and Sirikit Reservoirs (the Chao Phraya River Basin, Thailand). The optimal rule curves of each condition were used to assess by a Monte Carlo simulation. The results show that the shortest period of dry inflow record using in the simulation model in order to search the optimal rule curves is 10 year. Furthermore, the minimum initial capacity of reservoir for searching optimal rule curves is 10% of full capacity.