Hand dominance or handedness has been associated with a lot of other conditions; in the case of left handedness, most of them deleterious. Left handedness was also thought to adversely affect learning. In this study, self-assessment questionnaires were filled by 606 primary school pupils. Their ages ranged between 6 and 16 years, with a mean age of 11.1 and a mode of 12 years. The questionnaires were analysed using Chi-square test on SPSS. The handedness of the respondents was associated with learning, using their graded performance in class. There were 537 (94.9%) right-handers, thirty (5.1%) non-right handed children. A significant proportion of the non-right handed respondents performed above their class average. Handedness was thus found to significantly affect learning (p< 0.05).