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Journal of Applied Sciences
  Year: 2009 | Volume: 9 | Issue: 19 | Page No.: 3407-3423
DOI: 10.3923/jas.2009.3407.3423
Type 2 Diabetes: Genetic Advance and Aetiology
Mustafa Abdo Saif Dehwah, Zhang Shuang, Wang Zhen Hua, Wang Min and Qing-Yang Huang

Abstract:
The aim of this review was to discuss the current understanding of Type 2 Diabetes Mellitus (T2DM) genetic advance and aetiology. The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. Recent years have seen a tremendous surge in our understanding of the genetics of T2DM by Genome-Wide Association Study (GWAS). Approximately 20 genes consistently associated with T2DM mainly implicate pancreatic β-cell function in the pathogenesis of T2DM.
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How to cite this article:

Mustafa Abdo Saif Dehwah, Zhang Shuang, Wang Zhen Hua, Wang Min and Qing-Yang Huang, 2009. Type 2 Diabetes: Genetic Advance and Aetiology. Journal of Applied Sciences, 9: 3407-3423.

DOI: 10.3923/jas.2009.3407.3423

URL: http://scialert.net/abstract/?doi=jas.2009.3407.3423

 
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