The aim of this study was to investigate the short term
effect of aqueous-ethanolic extract of garlic in preventing and curing
nephropathy following induced diabetes in rats using streptozotocin (STZ),
with the help of stereological methods. Thirty two male wistar rats were
randomly divided into control, control+extract, diabetic and diabetic+extract
groups (n = 8). Diabetes was induced by intraperitoneal injection of 60
mg kg-1 of streptozotocin (STZ). Treatment with aqueous-ethanolic
extract of garlic (50 mg kg-1 day-1) was followed
for four weeks, then the left kidneys were excised and stereological studies
were carried out. The results revealed that blood sugar of the diabetic
rats was reduced significantly following treatment with garlic extract.
The final body weight of both diabetic and diabetic+extract groups didn`t
increase significantly, but in control and control+extract groups the
body weight increased significantly (p<0.001). A significant increase
in the kidney weight of the diabetic and diabetic+extract rats was found
(p<0.001) compared to the control ones. The volume of cortex, medulla
and total volume of kidney increased significantly in the diabetic and
diabetic+extract groups compared to the control ones. The total glomerular
volume increased significantly in diabetic rats compared to the other
groups (p<0.05). In conclusion the aqueous-ethanolic extract of garlic
influences the volume of total glomeruli but has no effect on the volume
of other kidney components.
S.M.A. Shariatzadeh, M. Soleimani Mehranjani, M. Mahmoodi, M.H. Abnosi, H.R. Momeni, A.R. Dezfulian and M. Noori, 2008. Effects of Garlic (Allium sativum) on Blood Sugar and Nephropathy in Diabetic Rats. Journal of Biological Sciences, 8: 1316-1321.