The goal of the present study was to evaluate the anticonvulsant property of Rosa damascena essence as a natural origin compound on the PTZ induced seizures in rats. To produce animal models with different graded of seizures (partial to generalized tonic-clonic seizures), PTZ was injected in 40 male Wistar rats. Prior to PTZ injections, the experimental groups of rats were received 500, 750 and 1000 mg kg-1 body weight essential oil. During the experimental period the epileptiform behaviors of all rats of different groups, was evaluated before and after essential injections. The results showed that the Rosa essential can attenuate the latent periods of the beginning of convulsions as well as the severity of seizures in a dose dependent manner. The flavonoids of Rosa damascena may act via GABAA receptors as pervious studies have proposed for flavonoids of other medicinal plants.
Masoumeh Kheirabadi, Ali Moghimi, Hassan Rakhshande and Morteza Behnam Rassouli, 2008. Evaluation of the Anticonvulsant Activities of Rosa damascena on the PTZ Induced Seizures in Wistar Rats. Journal of Biological Sciences, 8: 426-430.