Abstract:
In the present study, we examined the effects of maternal
hyperglycemia on the volume of brain and lateral ventricle in newborn Wistar
rats. At 7th day of pregnancy hyperglycemia was induced by a single injection
(i.p.) of streptozotocin (55 mg kg-1). Control animals were given
an equal volume of citrate buffer. After parturition 1 pups were randomly selected
from each litter, their brain dissected, fixed in 10% formalin, sectioned in
7 μm thickness and stained by H.E. By applying stereological techniques
and systematic random sampling scheme the volume of the brain and lateral ventricles
were estimated. In comparison with controls, statistical analysis showed significant
increases (p<0.05) in the volume of the brain and lateral ventricles. In
conclusion it seems that, maternal diabetes effect on blood brain barrier permeability
in newborn rats that could cause large amount of CSF generation. These effects
could lead to brain disorders such as hydrocephalus.
M. Tehranipour, J. Khayyatzade and Z. Ghorbani, 2009. Maternal Diabetes Induced Hydrocephaly in Newborn Rats. Journal of Biological Sciences, 9: 625-628.
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