Most diseases that affect honey bees are just a nuisance, but some are serious not only to the individual bees but to the whole colony. To diminish the impact of diseases in honey bees is of interest not just because of the well-being of the insects and the value of the honey that they produce for the beekeepers, but for the value of pollination that many important crops are dependent on. However, the decline in the bee populations seen recently had worried the scientific community, the beekeepers and the general public. Raising awareness about this threat has led to an extensive development of strategies that target protecting beehives and restore or increase honey bees population. Breeding for bees hygienic behavior as well as the use of biocontrol agents seem to be the most promising. The present review summarizes the various constraints facing honey bees as well as some of the recent progresses in controlling them.