Antibacterial and antifungal activity of 2-oxo benzylidine (3-oxo aniline) Cu (II)-ethylindiamine has been tested against a number of pathogenic bacteria and fungus with different doses. At dose 25 μg disc-1 the compound showed 6-13 mm diameter zone of inhibition against all of the tested bacteria which was found to be larger range as compared to cotrimoxazole (15-29 mm) at the same dose. Minimum inhibitory concentration was withinin the range of 64-128 μg ml-1 against all of the tested bacteria. The compound showed 0-13 mm diameter zone of inhibition against all of the tested fungus at dose 45 μg disc-1 which was found to be larger range as compared with nystatin. The brine shrimp lethality of the compound was found to be 5.23 μg ml-1 which shows a pronounced cytotoxic effect.
M. Asad-Ud-Daula, J.A. Khanam and A.Y.K.M. Masud Rana , 2004. Antibacterial and Antifungal Activity of 2-oxo Benzylidine (3-oxo Aniline)
Cu (II)-ethylidinediamine. Journal of Medical Sciences, 4: 124-127.