Abstract:
The effects of orally administered doses of Congo Red (CR) on rat testes weight, DNA and protein content as well as acid and alkaline phosphatase activities have been examined. Following 6 weekly exposure of group of rats to 5, 10, 20, 30 and 40 mg CR kg-1 body weight there was significant loss in testis weight of rats exposed to ≥20 mg CR kg-1 bd wt relative to the CR-free control rat testis (Control: 1.116±0.010 g; test (20 mg): 1.033±0.082 g). When compared to the control, the DNA obtained from the testis of rats exposed to ≥10 mg CR was statistically significantly lower (Control: 89.67±0.58 μg DNA g-1 tissue: test (10 mg) 84.50±1.00 μg DNA g-1). The protein content, the acid and alkaline phosphatase activities of the testes from CR-exposed rats did not differ significantly from that of CR-free control rats. Strong and significant correlation was demonstrated between the changes in testis weight and CR-dosage(r=-0.98; p<0.01), between its DNA content and CR-dosage (r =-0.77; p<0.10) and between testis weight change and changes in DNA level (r = +0.81; p<0.05)
F.O. Obi and M.A. Adaikpoh , 2004. Gravimetric and Biochemical Effects of Orally Administered Congo Red Dye on Rat Testes. Journal of Medical Sciences, 4: 90-94.
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