Abstract:
Six bioactive lectins were purified from the rootstock of Pondweeds(Potamogeton nodosus Poir) by conventional chromatographic methods. They showed cytotoxic effect in brine shrimp (Artemia salina L.) lethality bioassay. The LD-50values of PNL-1, PNL-2, PNL-3, PNL-4, PNL-5 and PNL-6 were found to be 10.76, 7.03, 17.25, 10.52, 19.60 and 20.1 μg mL-1, respectively which implied that they have significant uses specially of PNL-2. Experimental results revealed that PNL-2 and PNL-4 were more cytotoxic than other lectins.
F. Pervin, M.M. Hossain , S. Khatun , S.P. Siddique , K.A. Salam , M.R. Karim and N. Absar , 2006. Comparative Cytotoxicity Study of Six Bioactive Lectins Purified from Pondweed (Potamogeton nodosus Poir) Rootstock on Brine Shrimp. Journal of Medical Sciences, 6: 999-1002.
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