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Journal of Medical Sciences
  Year: 2008 | Volume: 8 | Issue: 5 | Page No.: 461-468
DOI: 10.3923/jms.2008.461.468
Expression and Clinical Implication of ZAP-70 in Acute Lymphoblastic Leukemia
M. Khorshied, H. Gouda, I.A. Mohsen, M. Sroor and Tark N. AL-Bolkeny

Abstract:
The purpose of this study was to investigate the expression of ZAP-70 in leukemic blasts of 40 newly diagnosed patients of B-cell acute lymphoblastic leukemia (B-ALL) by flow cytometry and to correlate its expression with the clinical and laboratory data as well as the response to induction chemotherapy together with CD20 as a maturational antigen (marker). ZAP-70 was expressed in 47.5% of cases (50% in adults and 45.8% in children). The highest expression was associated with pre and mature subtypes of B-ALL. ZAP-70 was significantly higher among the CD20 and Ig╬╝ positive cases, also it was associated with poor response to therapy especially in children, so it may have a prognostic value. Moreover, ZAP-70 could be a candidate molecule for targeted therapies in ALL.
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How to cite this article:

M. Khorshied, H. Gouda, I.A. Mohsen, M. Sroor and Tark N. AL-Bolkeny, 2008. Expression and Clinical Implication of ZAP-70 in Acute Lymphoblastic Leukemia. Journal of Medical Sciences, 8: 461-468.

DOI: 10.3923/jms.2008.461.468

URL: http://scialert.net/abstract/?doi=jms.2008.461.468

 
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