Vitiligo is a common complex skin disorder characterized by macular depigmentation
of skin, varying in size and shape caused by destruction of melanocytes.
A number of environmental and genetic factors have been implicated in
the etiology of vitiligo. The heterogeneity observed at clinical level
needs to be evaluated for an underlying genetic heterogeneity involving
autosomal and X-linked loci. Based on the clinical symptoms, vitiligo
is broadly classified into non-dermatomal and dermatomal. In order to
understand the various etiological/pathophysiological factors responsible
for different classes of vitiligo 3551 patients clinical data of
Indian origin was analyzed. The cases were grouped into different classes
based on the lesion type at the time of disease presentation. A significant
gender variation with male preponderance was observed in mucosal and acrofacial
compared to other classes. 2:1 male to female ratio in clinical variants
of vitiligo has been observed and has been used as a basis to hypothesize
the involvement of X-linked gene(s) along with autosomal genes in the
susceptibility to this polygenic condition.