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Journal of Medical Sciences
  Year: 2009 | Volume: 9 | Issue: 5 | Page No.: 219-226
DOI: 10.3923/jms.2009.219.226
Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy
Salwa M. El-Shebini, Lobna A. Ghattas, Hamed I. Mohamed, Maha I.A. Moaty, Salwa T. Tapozada and Laila M. Hanna

Abstract:
It has been proposed that obesity is associated with resistance to the biological effects of leptin hormone. The aim of this study was to demonstrate the effect of obesity on both serum leptin and its soluble receptor and to evaluate the effect of consumption of a special food formula combined with a restricted diet for obesity management. Thirty-two obese women volunteered to test a natural food formula in combination with a balanced hypo caloric-diet (both supply 900-1000 Kcal day-1) shared in a short term study, which lasted for four weeks. The formula was composed of whole sweet potato and carrot which were reduced to a flour form in 2:1 ratio and consumed as a pudding (20 g flour +100 mL boiled skimmed milk) for daily breakfast. Sweet potatoes and carrots are considered as a good source of dietary fibers, complex carbohydrates, antioxidants and phytochemicals. Subjects were divided into twenty-two obese women (group 1) with mean age (41.8±2.91 years) and body mass index (34.87±1.21), who followed the diet plus the pudding mixture; while ten obese women as a control (group 2) had a mean age of (43.4±2.28) and a body mass index of (36.57±1.31); who only followed the same diet. Relevant anthropometric measurements together with some biochemical parameters were determined before, after two and four weeks from the start of the regimen. Results showed although both groups lost weight comparably, group 1 (p<0.01,-3.55%), group2 (p<0.01,-2.01%), yet there were differences between them regarding serum leptin where in group 1 it was significantly decreased (p<0.01, -29.77%), with a concurrent increase in the serum soluble leptin receptor (p<0.05, +15.99%); in contrast to decreased levels of both leptin (-3.33%) and soluble leptin receptor (p<0.001, -5.05%) in group 2. Triglycerides levels were decreased (P<0.05,-22.62%) in group 1 in contrast to an increase (p<0.05, +39.40%) in group 2. In conclusion, incorporating custom-tailored food supplement in a slimming diet aiming at a quality weight loss that provides a healthier stable and durable metabolic environment should be considered.
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How to cite this article:

Salwa M. El-Shebini, Lobna A. Ghattas, Hamed I. Mohamed, Maha I.A. Moaty, Salwa T. Tapozada and Laila M. Hanna, 2009. Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy. Journal of Medical Sciences, 9: 219-226.

DOI: 10.3923/jms.2009.219.226

URL: http://scialert.net/abstract/?doi=jms.2009.219.226

 
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