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Journal of Medical Sciences

Year: 2013 | Volume: 13 | Issue: 4 | Page No.: 283-289
Research Article

Effect of L-arginine on Some Anthropometric Parameters of Metabolic Syndrome in Normal Female Wistar Rats

Anthony C.C. Egbuonu
Nutrition and Toxicological Biochemistry Unit, Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
Ifeoma I. Ijeh
Department of Biochemistry, College of Natural and Applied Sciences, Michael Okpara University of Agriculture Umudike, P.M.B. 7267 Umuahia, Abia State, Nigeria
Onyinye N.C. Egbuonu
Public Health Unit, Department of Health and Physical Education, University of Nigeria Nsukka, Nigeria
Lawrence U.S. Ezeanyika
Nutrition and Toxicological Biochemistry Unit, Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
Onyechi O. Obidoa
Nutrition and Toxicological Biochemistry Unit, Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
A reduction in the concentration of nitric oxide, a biosynthetic product of L-arginine (ARG) was associated with the pathophysiology of Metabolic Syndrome (MES). This study assessed the effect of ARG on some anthropometric parameters of MES in normal rats. Female wistar rats (60-80 g) were randomized into two groups (n = 8 animals) and exposed to 60 mg kg-1 (b.wt.) of ARG and 3 mL kg-1 b.wt. of distilled water respectively as treated and control groups. Twenty eight days oral exposure to ARG caused a significant (p<0.01) increase in feed efficiency (4.83±0.06 or 19.26 %) and total water consumption (0.83±0.17 L or 25.75%), but a significant (p<0.01) decrease in total feed intake (0.31±0.06 kg or 20.51%), indicating suppressed calorie storage or decreased energy balance that may improve MES. Changes observed in the rats final length (0.30±0.01 m or 3.45%), total body weight gain (0.05±0.01 kg or 16.66%), body mass index (1.24±0.15 kg m-2 or 1.59%) and lean body weight (0.27±0.03 kg or 0.73%) though insightful, were not significant (p>0.05), warranting follow up. From the results of Pearson correlations analysis, feed efficiency correlated negatively with total feed intake (p = 0.01) but positively (p = 0.05) with total water consumption, suggesting apparent synergy in the ARG-induced effects. Thus, ARG significantly improved some anthropometric parameters of MES, hence may improve some MES features related to excessive calorie build up or storage in the female rats. The findings warrant similar studies on a longer duration for meticulousness.
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