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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 5 | Page No.: 465-472
DOI: 10.3923/jpt.2007.465.472
Effect of Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats
B. Rajkapoor, V. Ravichandran , M. Gobinath , J. Anbu , N. Harikrishnan , M. Sumithra , M. Sankari , R. Venugopal and D. Sakthisekaran

Abstract:
Effect of ethanol extract of Bauhinia variegata (EBV) was evaluated for antiarthritic activity on complete Freund’s adjuvant (CFA) induced arthritis in rat. The EBV was administered orally at the dose level of 250 mg kg-1 for 15 days. The paw volume was measured at 3rd, 5th, 10th and 15th days. At the end of these 15 day, the animals were sacrificed and various biochemical parameters such as serum aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol and triglycerides were estimated. Antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and lipid peroxide (LPO) in liver and kidney of normal, arthritic control and EBV treated rats were studied. Oral administration of EBV effectively inhibits rat paw edema volume. EBV significantly (p<0.01) altered the biochemical parameters which got affected in arthritic rats. There was a significant alteration in LPO, SOD, catalase and GPx levels when compared to arthritic control rats. Our finding showed a significant antiarthritic effect of EBV against CFA induced arthritis in rats.
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How to cite this article:

B. Rajkapoor, V. Ravichandran , M. Gobinath , J. Anbu , N. Harikrishnan , M. Sumithra , M. Sankari , R. Venugopal and D. Sakthisekaran , 2007. Effect of Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats. Journal of Pharmacology and Toxicology, 2: 465-472.

DOI: 10.3923/jpt.2007.465.472

URL: http://scialert.net/abstract/?doi=jpt.2007.465.472

 
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