Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
Journal of Pharmacology and Toxicology
  Year: 2008 | Volume: 3 | Issue: 6 | Page No.: 449-456
DOI: 10.3923/jpt.2008.449.456
Anticancerous Effect of Typhonium flagelliforme on Human T4-Lymphoblastoid Cell Line CEM-ss
S. Mohan, A. Bustamam, S. Ibrahim, A. S. Al-Zubairi and M. Aspollah

Abstract:
Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T. flagelliforme in these cancers. The purpose of the present study was to investigate the potential in vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Molecular Diagnostics and Therapy of Acute Myeloid Leukemia
How to cite this article:

S. Mohan, A. Bustamam, S. Ibrahim, A. S. Al-Zubairi and M. Aspollah, 2008. Anticancerous Effect of Typhonium flagelliforme on Human T4-Lymphoblastoid Cell Line CEM-ss. Journal of Pharmacology and Toxicology, 3: 449-456.

DOI: 10.3923/jpt.2008.449.456

URL: http://scialert.net/abstract/?doi=jpt.2008.449.456

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved