A Streptomyces bacterium, designated AZ-C442 was isolated from a soil sample collected from Luxor governorate, Egypt. Phylogenetic analysis based on 16S rRNA gene sequences and culture characteristics demonstrated strain AZ-C442 affiliation to the genus Streptomyces tanashiensis. This strain exhibited inhibitory activity against gram-positive and gram-negative bacteria and unicellular and filamentous fungi by evaluation of optimum environmental and nutritional conditions. It was found that the Streptomyces tanashiensis AZ-C442 produced and excreted into the culture medium a large amount of the compound, which was isolated, purified and structurally characterized as known Luteomycin like antibiotic on the basis of combined spectral analyses which indicates a suggested impirical formula of C15H30N2O10. Luteomycin showed inhibitory effects against Staphylococcus aureus, Klebsiella pneumonia,Escherichia coli and Salmonella typhi, moreover, against Aspergillus flavus, Alternaria alternate and Saccharomyces cerevisiae.
M.M. Afifi, H.M. Atta, A.A. Elshanawany, U.M. Abdoul-Raouf and A.M. El-Adly, 2012. Identification of Luteomycin like Antibiotic Produced by Streptomyces tanashiensis AZ-C442 Isolated from Luxor Governorate at Upper Egypt. Microbiology Journal, 2: 1-22.