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Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 8 | Page No.: 1123-1125
Research Article

Antinociceptive Activity of Methanol Extract of Solanum sisymbrifolium Lamk.

J. A. Shilpi
Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
R. Rouf
Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
M.A. M. Sarker
Department of Pharmacology and Therapeutics, Khulna Medical College, Khulna 9000, Bangladesh
Qamrunnahar
Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
M. M. Ferdous
Department of Botany, University of Rajshahi, Rajshahi 6205, Bangladesh
S. J. Uddin
Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
The antinociceptive activity of the methanolic extract of the whole plant of Solanum sisymbrifolium Lamk. was investigated using acetic acid-induced writhing model in swiss albino mice. At the doses of 125, 250 and 500 mg kg 1 body weight, the extract showed 44.19, 59.53 and 73.02% writhing inhibition, respectively in test animals which were comparable to that of standard drug aspirin (85.12%) and the results were statistically significant (p<0.001). At the above doses, the extract exhibited significant and dose dependant antinociceptive activity in acetic acid-induced writhing model in mice. Phytochemical investigation of the extract indicated the presence of alkaloid, flavonoids, steroid and tannin.
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