A study was designed to examine the effects of dietary
flaxseed oil (FO) and sesame oil (SO) which are rich successively in n-3
and (n-9 and n-6) on biochemical parameters and histological status of
bone. Sixty-four 90-day-old female wistar rats were randomly assigned
to 6 groups: sham-operated rat (sham)+ control diets, ovariectomized rat
(OVX))+ control diets, OVX+ 7% FO, OVX+ 7% SO, OVX+ 10% FO, OVX+ 10% SO.
After 4 weeks of treatments, rats were euthanized; blood and tissues were
collected for analyses. Markers of bone formation which is alkaline phosphatase
activity and markers of bone resorption which is tartrate resistant acid
phosphatase activity were measured. Present results showed that OVX increased
significantly ALP and TRAP activity and the examination of bone tissue
showed disruptive and lytic bone trabeculae. Animals fed 10% FO and 10%
SO of fat reduced these parameters and improved bone microarchitecture.
Whereas, there was no improvement in biochemical and histological states
in OVX rats that received 7% of PUFAs successively provided from FO and
SO diets. In conclusion, our results are encouraging because they suggest
that PUFAs intake may help to prevent osteoporosis associated with estrogens
deficiency. However, further studies are needed to determine the mechanism
by which a diet rich in n-3 or lignans modulate bone tissue.
S. Boulbaroud, A. Mesfioui, A. Arfaoui, A. Ouichou and A. El Hessni, 2008. Preventive Effects of Flaxseed and Sesame Oil on Bone Loss in Ovariectomized Rats. Pakistan Journal of Biological Sciences, 11: 1696-1701.