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Pakistan Journal of Biological Sciences
  Year: 2013 | Volume: 16 | Issue: 16 | Page No.: 770-778
DOI: 10.3923/pjbs.2013.770.778
Role of Acorus calamus and α-asarone on Hippocampal Dependent Memory in Noise Stress Exposed Rats
Manikandan Sundaramahalingam, Srikumar Ramasundaram, Sheela Devi Rathinasamy, Ruvanthika Pulipakkam Natarajan and Thangam Somasundaram

Abstract:
Stress is a condition or stimulus that threatens an organism’s survival. Noise is an environmental stressor. It is well known that long term as well as acute exposure to noise led to oxidative stress. In the present study, it was investigated that the persistence of noise stress (100 dBA/4 h/d for 30 days) could cause memory impairment in rats and whether ethylacetate extract of AC EAAC (50 mg kg-1 b.wt.) and α-Asarone (9 mg kg-1 b.wt.). treatment can prevent or not. In order to understand the possible mechanism behind it, antioxidant status and acetylcholinesterase (AChE) activity in hippocampus was evaluated after rats were tested in Radial Eight-arm Maze (RAM). Heat shock protein 70 (hsp 70) expression in hippocampus was also evaluated to understand the intensity of stress level. Results showed that after noise stress exposure, time taken to visit all the baited arms, working and reference memory errors were increased in RAM. The superoxide dismutase, lipid peroxidation, AChE activity, hsp 70 were significantly increased with concomitant decrease in catalase, glutathione peroxidase activity and G6PD activity of non-enzymatic levels was observed in the 30 days noise stress exposed group. When rats were co-administrated with EAAC and α-Asarone prevents the noise stress induced alterations significantly. In Conclusion, noise stress induced oxidative stress, increased AChE activity, and over expression of hsp 70 in hippocampus region might have led to the impairment of spatial memory. EAAC and α-Asarone prevents this noise stress induced memory impairment.
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How to cite this article:

Manikandan Sundaramahalingam, Srikumar Ramasundaram, Sheela Devi Rathinasamy, Ruvanthika Pulipakkam Natarajan and Thangam Somasundaram, 2013. Role of Acorus calamus and α-asarone on Hippocampal Dependent Memory in Noise Stress Exposed Rats. Pakistan Journal of Biological Sciences, 16: 770-778.

DOI: 10.3923/pjbs.2013.770.778

URL: http://scialert.net/abstract/?doi=pjbs.2013.770.778

 
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