One of the major problems in obstetrics and pediatrics is
preterm birth. A new method of prediction of preterm birth is by salivary estriol.
This study aimed to determine the predictive value of single measurement of
salivary estriol and its relationship with preterm birth. In this study, the
salivary specimens of 466 pregnant women of 25-34 weeks gestational age were
collected and kept in a freezer until delivery. Consequently, the salivary specimens
were thawed and estriol levels were measured. The cut-off point for estriol
was determined by a receiver operating characteristics curve. Salivary estriol
levels equal to or higher than the cut-off point (2.6 ng mL-1) were
considered as the estriol (+) group and those lower than 2.6 ng mL-1
were considered as the estriol (-) group. Our findings showed that 36 (18.3%)
subjects in the estriol (+) group and 22 (8.2%) subjects in the estriol (-)
group had preterm deliveries. There was a significant relationship between salivary
estriol levels and preterm birth (χ2 = 10.636, p = 0.001). Sensitivity,
specificity and predictive values (positive and negative) of estriol were 62,
60, 18.3 and 82%, respectively. Single measurement of salivary estriol at 25-34
weeks of gestation, with its high negative predictive values, could be beneficial
to identify women who will not develop preterm labor. This outcome suggests
that unnecessary interventions should be avoided to prevent preterm births.
Khani Soghra, Shahhosseini Zohreh, Abedian Kasgari Kobra and Mahdavi Mohammad Reza, 2014. Single Measurement of Salivary Estriol as a Predictor of Preterm Birth. Pakistan Journal of Biological Sciences, 17: 730-734.