Abstract:
The aim of the present study was investigation of antitoxin
effects of green tea on malathion toxicity in rats. Forty eight rats were
divided into 4 groups, control, extract green tea (1% w/v, daily), malathion
(135 mg kg-1 i.p., daily) and rats injected with malathion
and treated with crude green tea. After 5 weeks, the animals were weighed
and autopsied for detailed histopathological and haematological studies
on the last day after final dosing. Insignificant changes in blood hemoglobin
was shown when compared to control except increase in WBC count (p≤0.05)
and significant decrease in RBC count (p≤0.05). Histopathological findings
of lung tissue samples were significantly different in comparison of controls
and the experimental rats, where the normal alveolar structure in group
1, 2 and 4, but increased alveolar macrophages and interstitial neutrophil
infiltration and minimal fibrosis were detected in malathion group. The
repair and recover of lung tissue injuries occur in group 4 may due to
the antioxidant, antitoxin and chemopretective properties of different
components of green tea. So, the present study recommends that the using
crude green tea or active biological components in prevention the toxicity
of pesticides such as malathion.
Attalla Farag El-Kott and Mashael Mohammed Bin-Meferij, 2008. Influence of Green Tea on Haematological and Lung Histological Disorders Induced by Malathion in Rats. Research Journal of Environmental Toxicology, 2: 85-91.
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