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Research Journal of Phytochemistry
  Year: 2013 | Volume: 7 | Issue: 1 | Page No.: 10-17
DOI: 10.3923/rjphyto.2013.10.17
Variation of Body Temperature after Administration of Amino Acid Amides
Y. Ogawa, A. Minamizawa, S. Tada and T. Konishi

Oxypinnatanine, a unique derivative of glutamic acid or glutamine with a furfuryl group increased the total time of NREM sleep by an oral administration. However the mechanism by which oxypinnatanine promotes sleep remains to be clarified. In this study, the effect of oxypinnatanine on heat release of freely moving mice from peripheral blood vessel was demonstrated by using thermography. Oxypinnatanine given at 30 mg kg-1 indicated the transient skin temperature elevation from 2 min after its administration but the skin temperature was decreased from 32 min after. Therefore, it is possible that the thermal release associated with the dilation of peripheral vessels is one of the mechanisms of oxypinnatanine about its promoting sleep. In addition, the effects of amino acid amides (30 mg kg-1) which isolated from Hemerocallis fulva var. sempervirens was also examined. As a result, pinnatanine and kwansonine A decreased the temperature, while longitubanine A, longitubanine B and kwansonine B did not. As changes in body temperature are generally associated with concomitant changes in sleep propensity and the effects of sleep promoting substances are related to changes in thermoregulation. Therefore, it is possible that the monitoring on heart release from peripheral blood vessel with the use of thermography might enable the search for substances which induce sleep.
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How to cite this article:

Y. Ogawa, A. Minamizawa, S. Tada and T. Konishi, 2013. Variation of Body Temperature after Administration of Amino Acid Amides. Research Journal of Phytochemistry, 7: 10-17.

DOI: 10.3923/rjphyto.2013.10.17






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