Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
Asian Journal of Animal and Veterinary Advances
  Year: 2012 | Volume: 7 | Issue: 3 | Page No.: 225-234
DOI: 10.3923/ajava.2012.225.234
Comparison of the Effects of Tocotrienol and Estrogen on the Bone Markers and Dynamic Changes in Postmenopausal Osteoporosis Rat Model
Ahmad Tantawi Aktifanus, Ahmad Nazrun Shuid, Nurul Hashimah A. Rashid, Tam Heng Ling, Chua Yin Loong, Nurulhayati M. Saat, Norliza Muhammad, Norazlina Mohamed and Ima Nirwana Soelaiman

Abstract:
The standard treatment for postmenopausal osteoporosis is Estrogen Replacement Therapy (ERT) but it was associated with serious adverse effects such as breast cancer and cardiovascular disease. There is a need to find other alternatives for the treatment of post-menopausal osteoporosis. Vitamin E especially tocotrienol was shown to have anti-osteoporosis effects in many animal osteoporotic models but it has never been compared to estrogen. This study aimed to compare the effects of tocotrienol-enriched fraction to estrogen on the bone biochemical markers and dynamic histomorphometric changes using ovariectomised rats as the postmenopausal osteoporosis model. Thirty-two female Sprague-Dawley rats were randomly divided into groups of sham-operated (SHAM), ovariectomised control (OVC), ovariectomised+60 mg kg-1 tocotrienol-rich fraction (OV+T) and ovariectomised+64.5 μg kg-1 of premarin® (OV+ERT). The rats were treated for two months and the serum osteocalcien and serum C-telopeptide of type 1 collagen (CTX) were measured using ELISA technique, while the femoral dynamic changes were analysed histomorphometrically. The CTX levels were found to be lowered compared to the pre-treatment levels for all the groups. Only the osteocalcin level of OV+ERT group was significantly reduced compared to its pre-treatment level. Dynamic histomorphometric analysis showed that both the OV+ERT and OV+T groups have lower single-labeled surface/bone surface (sLS) but higher double-labeled surface/bone surface (dLS), bone formation rate/bone surface (BFR) and mineral apposition rate (MAR) compared to the BC and OVC groups. The OV+T group showed better effects on most of the dynamic parameters compared to the OV+ERT group. Therefore, in postmenopausal osteoporosis model, tocotrienol-rich fraction has shown better bone protective effects than ERT.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Effect of Dietary Tocotrienols on Antioxidant Status and Low Density Lipoprotein Oxidation in Rats, Exposed to Cigarette Smoke
  •    Comparison of the Effects of Tocopherol and Tocotrienol on Osteoporosis in Animal Models
How to cite this article:

Ahmad Tantawi Aktifanus, Ahmad Nazrun Shuid, Nurul Hashimah A. Rashid, Tam Heng Ling, Chua Yin Loong, Nurulhayati M. Saat, Norliza Muhammad, Norazlina Mohamed and Ima Nirwana Soelaiman, 2012. Comparison of the Effects of Tocotrienol and Estrogen on the Bone Markers and Dynamic Changes in Postmenopausal Osteoporosis Rat Model. Asian Journal of Animal and Veterinary Advances, 7: 225-234.

DOI: 10.3923/ajava.2012.225.234

URL: http://scialert.net/abstract/?doi=ajava.2012.225.234

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved