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| Protective Effect of Metformin on Cardiac and Hepatic Toxicity Induced by Adriamycin in Swiss Albino Mice
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A.M. Aleisa,
S.S. Al-Rejaie,
S.A. Bakheet,
A.M. Al-Bekairi,
O.A. Al-Shabanah,
Abdulhakeem Al-Majed,
Abdulaziz A. Al-Yahya
and S. Qureshi
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Abstract:
Diabetes Mellitus (DM) is a chronic disease that is characterized
by deterioration of glycemic control. The disease is known to be caused
by imbalance between Reactive Oxygen Species (ROS) and antioxidant defense
systems. Hyperglycemia is commonly observed in a wide variety of diseases,
including cancer. Although, therapy against glycemic control is used in
all these diseases, the diabetic cancer patients are on additional therapy
with anticancer drugs. The objective of present study was to investigate
if metformin, a very popular antidiabetic agent can avert the cardiac
and hepatic toxicity caused by Adriamycin (ADR), which is a commonly used
cytotoxic drug. The experimental protocol included oral treatment of mice
with different doses (62.5, 125 and 250 mg kg-1 day-1)
of metformin for 7 days. Some mice in each group were injected i.p. with
ADR (15 mg kg-1), 24 h prior to sacrifice. In each case animals
were killed, 24 h after the last treatment, blood sample was collected
and plasma was separated for analysis of AST, ALT and CK-MB. Liver and
heart from the same animals were excised for analysis of proteins, nucleic
acids, MDA and NP-SH. The results obtained revealed that pretreatment
with metformin (i) reduced the ADR-induced increase in the concentrations
of AST, ALT and CK-MB (ii) protected against the ADR-induced increase
of MDA and decrease of DNA and NP-SH in both cardiac and hepatic tissues.
These results demonstrate that the treatment with metformin might be useful
to protect cardiac and hepatic toxicity. The exact mechanism of action
is not known, however; the inhibition of ADR-induced increase of plasma
enzymes and MDA and depletion of DNA and NP-SH by metformin may be attributed
to its antioxidant potentials, which are well known for the reduction
of glycotoxins and general improvement in cellular dysfunction. The use
of Metformin by cancerous diabetic patients on cytotoxic therapy will
be a boon to avert the cardiac and hepatic toxicity.
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How to cite this article:
A.M. Aleisa, S.S. Al-Rejaie, S.A. Bakheet, A.M. Al-Bekairi, O.A. Al-Shabanah, Abdulhakeem Al-Majed, Abdulaziz A. Al-Yahya and S. Qureshi, 2008. Protective Effect of Metformin on Cardiac and Hepatic Toxicity Induced by Adriamycin in Swiss Albino Mice
. Asian Journal of Biochemistry, 3: 99-108.
DOI: 10.3923/ajb.2008.99.108
URL: http://scialert.net/abstract/?doi=ajb.2008.99.108
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