Genotoxic effects of hazards at the environmental and occupational exposure contribute to ageing acceleration. These compounds induce genetic damages in the exposed cells such as buccal cells. The study was carried out on the mechanical workshop workers to investigate micronuclei (MN) formation in the exposed subjects. The formation in the cells was evaluated by using MN test. The applied buccal cells as sensitive sources showed the genotoxic and cytotoxic damages which could accompany ageing. Difference in MN frequency between the workers and controls was statistically significant (p = 0.001). It showed statistically significant difference between the older and younger groups in the workers and controls (p = 0.001) as well. The results showed that the occupational exposure increased MN frequency in the workers. It was concluded that the induced genomic damages could act as an accelerating factor to enhance the speed of ageing in the workers.
Sima Ataollahi Eshkoor, Patimah Ismail, Sabariah Abd Rahman, Saidi Moin and Mohd Yusoff Adon, 2011. Occupational Exposure as a Risk Factor to Enhance the Risk of Early Ageing. Asian Journal of Biotechnology, 3: 573-580.