Cancer is one of the leading causes of death worldwide. Anti-cancerous activity is the effects of natural, synthetic or biological chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. An attempt has been made to review important medicinal plants used for the treatment and prevention of neoplasm from Uttarakhand. This article considered 24 plants from the state having anti-cancerous property. These plants contain several anti-cancerous bioactives such as saponins, flavonoids, polyphenols, tannins and alkaloids etc. This study also incorporates the ethno-botany and biological activities of these important plants.