Abstract: In vitro studies were carried out to evaluate the cytotoxic potential of the ethanolic and aqueous extracts from stem of Dendrophthoe falcata against human breast cancer cells (MCF-7). Screening of these extracts was done using the brine shrimp lethality bioassay, MTT assay and SRB assay. The results showed the significant decrease of the viability of the cells in a concentration-dependent manner. The ethanolic extract of D. falcata showed IC50 107 μg mL-1 in MTT assay and 112 μg mL-1 in SRB assay for MCF-7 cells and thus showed significant cytotoxic activity. The aqueous extract of D. falcata demonstrated higher activity with IC50 90 μg mL-1 in MTT and 98 μg mL-1 in SRB assay for MCF-7 cells, respectively after 48 h of exposure. In brine shrimp lethality bioassay also aqueous extract showed more potent cytotoxicity with LC50 90 μg mL-1 as compared to ethanolic extract with LC50 120 μg mL-1. From results obtained it was observed that both extracts of D. falcata may be a promising alternative to synthetic substances as natural compound with high antiproliferative activities and to be useful in cancer treatment and prevention.
Nipun Dashora, Vijay Sodde, Kirti S. Prabhu and Richard Lobo, 2011. In vitro Cytotoxic Activity of Dendrophthoe falcata on Human Breast Adenocarcinoma Cells-MCF-7. International Journal of Cancer Research, 7: 47-54.