The present research proved that grape seed extract could be used as hypocholesterolemic agent. Research: GSE was subjected to a series of experiments to document its AA, safety for use as a food supplement and/or phytochemical drug. We further compared the effects of GSE on the prevention and treatment of hypercholesterolemia. Our GSE was proven to have a potent AA and more efficient than ascorbic acid (Vitamin C), in addition to its safety for use as nutritional supplement where the LD50 value was 6.3 g kg-1. On other word, GSE is not toxic. The hypolipidemic effect of GSE was investigated at two levels, the preventive level and treatment level. It was found that GSE could prevent the hypercholesterolemia on which GSE lowered serum Total Cholesterol (TC) by 32%, Low-Density Lipoprotein (LDL) by 40% and elevated the High-Density Lipoprotein (HDL) by 23%. The current research, shows for the first time that GSE could be used for the treatment of hypercholesterolemia on which GSE reduced the serum TC by about 42% and LDL-C about 56%, while had elevation effect on the serum HDL-C by 56%. Therefore, both the LDL-C/HDL-C ratio and TC/HDL-C ratio were decreased by more than half, thus determining an improvement in the atherosclerotic risk index. In conclusion, GSE showed an obvious hypocholestrolemic effect that may have important pharmaceutical applications in the prevention and treatment of cardiovascular disease and atherosclerosis.
Hala El-Adawi , Mohamed Abdel Mohsen , Dalia Youssef and Shehata El-Sewedy , 2006. Study on the Effect of Grape Seed Extract on Hypercholestrolemia: Prevention and Treatment
. International Journal of Pharmacology, 2: 593-600.