Abstract:
The aim of the present study was to investigate the
biological effects of aqueous herbal extracts mixed with stirred yoghurt
filtrate against alloxan-induced oxidative stress and diabetes in rats.
Aqueous extracts of six medicinal plants: fenugreek, greater burdock,
goat`s rue, colocynth, chicory and lupine were mixed with stirred yoghurt
filtrate and used in the experiments. Blood glucose and alanine and aspartate
aminotransferase (ALT and AST) activities were estimated before and after
alloxan-induced oxidative stress and diabetes in rats. Obtained results
showed that blood glucose levels in sera of treated rats fed on aqueous
extract of medicinal plants and stirred yoghurt filtrate mixture decreased
with mean values of 135.0 ± 26.85 mg/100 mL serum compared with
the treated rat fed on basal diet (positive control) with mean value of
237.66 ± 14.43 mg/100 mL serum. Data showed that ALT and AST activities
in sera of treated rat fed on aqueous extract of medicinal plants and
stirred yoghurt filtrate mixture were nearest to the level of un-treated
rats fed basal diet (negative control). The means values of ALT and AST
level in treated group fed on aqueous extract of medicinal plants and
stirred yoghurt filtrate mixture were 57.33 ± 20 and 189.33 ±
48.85 compared with the positive control 90 ± 31.76 and 260.00
± 57.27 and negative control 44.66 ± 9.5 and 180.66 ±
23.58 U L-1, respectively. Data concluded that mixture of medicinal
plant extracts and stirred yoghurt filtrate may play a role in protection
against alloxan-induced oxidative stress and diabetes in rat.
N.A. Al-Wabel, H.M. Mousa, O.H. Omer and A.M. Abdel-Salam, 2008. Biological Evaluation of Aqueous Herbal Extracts and Stirred Yoghurt Filtrate Mixture Against Alloxan-Induced Oxidative Stress and Diabetes in Rats. International Journal of Pharmacology, 4: 135-139.
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