Abstract:
An herbal cocktail comprising of seeds, stem and leaves of seven African
plants extensively used in South-Western Nigeria for the management and
treatment of inflammation and tumor of the breast was investigated for
analgesic and anti-inflammation activities. The analgesic properties of
the ethanol extract was investigated using three in vivo mice test
models (mice constriction, hot-plate and formalin-induced pain test) while
anti-inflammatory activities of the same were evaluated using the Carageenan
and egg albumin-induced oedema test systems in vivo. Present findings
indicated that the cocktail at a concentration of 400-1600 mg kg-
produced significant inhibition (p<0.05) response in both phases of
the formalin pain model. The acetic acid-induced abdominal constriction
also showed a dose dependent pain inhibition pattern directly related
to the amount of extract administered. Instructively, the extract exhibited
higher analgesic activity than acetylsalicylic acid but lower than morphine
(2 mg kg-). The cocktail (400-1600 mg kg-) exhibited
anti-inflammatory activity but inhibition observed at 1600 mg kg-
in the 5 and 6 h was very significant. It compared favourably with the
reference drug (Indomethacin 10 mg kg-). Consequently, it is
our suggestion that the cocktail may possess analgesic and anti-inflammatory
properties.
A.M. Oloyede, J. Okpuzor, O. Omidiji and H.O.C. Mbagwu, 2008. A Pharmacological Evaluation of A Herbal Cocktail. International Journal of Pharmacology, 4: 196-201.
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