The aim of this study was to investigate the effect
of Chloroquine phosphate (at therapeutic dose) on existing gastric ulceration
in albino rats. Rats were treated with Chloroquine phosphate (8.5 mg kg-1)
intramuscularly for 24 h after formation of ulcers induced by acidified
ethanol and indomethacin. Following sacrifice, colorimetric assays were
applied to determine the concentration of protein and mucus, activities
of catalase and lipid peroxidation in homogenized gastric mucosal samples.
Chloroquine phosphate worsens gastric lesions produced by both indomethacin
and acidified ethanol. Also, it seemed to elaborate the indomethacin and
acidified ethanol induced effects on gastric juice volume, pH and acid
output. On the other hand, thiobarbituric acid reactants (TBAR) was further
increased and protein, catalase and mucus were decreased in the gastric
mucosal samples. The data indicates that the use of Chloroquine may be
dangerous to the integrity of the stomach, especially in existing gastric
ulcers. It increases oxidative stress in the gastric mucosa caused by
indomethacin and acidified ethanol.