Abstract:
The aqueous extract of polyherbal Ayurvedic preparation
PD-10 (from the roots of Hemidesmus indicus R. Br. (Asclepiadaceae),
Rubia cordifolia L. (Rubiaceae), Cissampelos pareira L.
(Menispermaceae); fruits of Terminalia chebula Retz. (Combretaceae),
Emblica officinalis Gaertn. (Euphorbiaceae), Terminalia bellirica
Roxb. (Combretaceae), Vitis vinifera L. (Vitaceae), Grewia
asiatica L. (Tiliaceae), Salvadora persica L. (Salvadoraceae)
and granules of Saccharum officinarum L. (Poaceae)) was investigated
for antipyretic property. The extract caused significant (p<0.05) antipyretic
activity induced pyrexia by using Brewer`s yeast in rats. The evaluation
of analgesic activity of PD-10 using acetic acid induced writhing model,
hot plate method and tail immersion methods in mice revealed very significant
(p<0.01) analgesic activity. The ulcerogenicity effect of PD-10 studied
at different dosages by Barret`s method in rats showed significantly lesser
ulcer effect even at very high dosage as compared to that of aspirin.
These data confirm the antipyretic, analgesic and ulcerogenic properties
of the polyherbal Ayurvedic preparation (PD-10) as enunciated in the traditional
texts.
M. Gupta, B.P. Shaw and A. Mukerjee, 2008. Studies on Antipyretic-Analgesic and Ulcerogenic Activity of Polyherbal Preparation in Rats and Mice. International Journal of Pharmacology, 4: 88-94.
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