Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 652-657
DOI: 10.3923/ijp.2010.652.657
Evaluation of Free Radical Scavenging, Anti-inflammatory and Analgesic Potential of Benincasa hispida Seed Extract
N.S. Gill, K. Dhiman, J. Bajwa, P. Sharma and S. Sood

Abstract:
The present study was designed to investigate the free radical scavenging, anti-inflammatory and analgesic potential of methanolic extract of Benincasa hispida seeds (MEBH). Free radical scavenging potential of MEBH was evaluated by DPPH (1,1-diphenyl-2-picryl-hydrazyl) and hydrogen peroxide (H2O2) method. The extract showed significant free radical scavenging activity in a dose dependent manner when compared with ascorbic acid. The highest radical scavenging activity of MEBH was found to be 79.8% at concentration of 300 μg mL-1. The H2O2 scavenging effect of MEBH was 63.7% at a concentration of 200 (μg mL-1). Further, the extract was studied for its anti-inflammatory and analgesic activities at the dose level of 100, 200 and 300 mg kg-1. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema in rats. Analgesic activity was evaluated by tail immersion and tail flick methods in mice. The extract showed significant decrease in paw volume (59.7% reduction) and pain at the dose level of 300 mg kg-1 when compared with reference drug diclofenac and morphine, respectively. The MEBH may be useful as a natural antioxidant in the treatment of inflammation and pain.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Synthesis of Quinazolinone Based Schiff Bases as Potential Anti-inflammatory and Analgesic Agents
  •    Evaluation of Free Radical Scavenging, Anti-inflammatory and Analgesic Potential of Luffa echinata Seed Extract
  •    Synthesis of 2,4,5-Triphenylimidazoles Novel Mannich Bases as Potential Antiinflammatory and Analgesic Agents
  •    Evaluation of Antioxidant, Antiinflammatory and Antiulcer Potential of Momordica charantia Methanolic Seed Extract
  •    Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. Seed Extract in Rats
  •    Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat
How to cite this article:

N.S. Gill, K. Dhiman, J. Bajwa, P. Sharma and S. Sood, 2010. Evaluation of Free Radical Scavenging, Anti-inflammatory and Analgesic Potential of Benincasa hispida Seed Extract. International Journal of Pharmacology, 6: 652-657.

DOI: 10.3923/ijp.2010.652.657

URL: http://scialert.net/abstract/?doi=ijp.2010.652.657

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved